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oral naltrexone is effective in the treatment of alcohol and opiate dependence; however, a major limitation of its clinical utility is poor patient adherence to the daily dosing schedule.
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the placebo-controlled studies that demonstrated the efficacy of naltrexone hydrochloride as an adjunctive treatment of alcoholism used a dose regimen of naltrexone hydrochloride 50 mg once daily for up to 12 weeks.
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