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Following a single oral dose of 14 c-labeled olanzapine, 7 of the dose of olanzapine was recovered in the urine as unchanged drug, indicating that olanzapine is highly metabolized.
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kalinichevsa korneevpg clifton2009hyperphagia and increased meal size are responsible for weight gain in rats treated sub-chronically with olanzapine.
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in a single 8-week randomized, double-blind, fixed-dose study comparing 10 n 199 , 20 n 200 and 40 n 200 mg day of oral olanzapine in adult patients with schizophrenia or schizoaffective disorder, mean baseline to endpoint increase in weight 10 mg day 1.
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