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The major circulating metabolites are the 10-n-glucuronide and 4 -n-desmethyl olanzapine; neither metabolite has any pharmacological activity.

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table 11 summarizes the most commonly reported adverse reactions 10 of the clozapine tablets or olanzapine group in the intersept study.

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the clinical effect of this interaction is thought to be minimal; however, the clinician should be alert for reduced olanzapine effect if the drugs are coadministered.

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citalopram causes dose-dependent qt interval prolongation and olanzapine is associated with a risk for qt prolongation and torsade de pointes tdp .

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