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Pregnancy should be avoided if either partner is receiving methotrexate; during and for a minimum of 3 months after therapy for male patients, and during and for at least one ovulatory cycle after therapy for female patients.
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Significant drug interactions include increased risk of nephrotoxicity when used with other nephrotoxic agents such as cyclosporine, as well as the potential to increase serum concentrations of methotrexate, with which acyclovir competes for renal excretion.
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Close attention to renal function including adequate hydration, urine alkalinization and measurement of serum methotrexate and creatinine levels are essential for safe administration.
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