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A third study, also a flexible-dose study comparing paroxetine 20 to 50 mg daily to placebo, demonstrated paxil to be significantly superior to placebo on change from baseline for caps2 total score, but not on proportion of responders on the cgi-i.
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Paxil has long been a source of concern by physicians, who have expressed fears it leads patients to have suicidal thoughts.
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Bupropion is one of the most widely prescribed antidepressants, and the available evidence indicates that it is effective in clinical depression 16 as effective as several other widely prescribed drugs, including fluoxetine prozac and paroxetine paxil , 17 although trends favoring the efficacy of escitalopram lexapro , sertraline zoloft and venlafaxine effexor over bupropion have been observed.
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