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Current expert recommendation is to take 5 mg once a week, eg on a friday monday for methotrexate, friday for folic acid .

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confusion difficulty falling asleep or staying asleep dizziness excessive tiredness fast heartbeat pale skin shortness of breath sore throat, chills, fever or other signs of infection unusual bruising or bleeding weakness methotrexate may cause a severe rash that can be life-threatening.

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5 mg to 20 mg per week, the combination of nsaids and methotrexate have been used without issue.

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other rarer reactions related to or attributed to the use of methotrexate such as nodulosis, vasculitis, arthralgia myalgia, loss of libido impotence, diabetes, osteoporosis, sudden death, reversible lymphomas, tumor lysis syndrome, soft tissue necrosis and osteonecrosis and anaphylactoid reactions have been reported.

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in patients with partial responses to methotrexate, additional medications are usually added to rather than substituted for methotrexate to achieve combination therapies.

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some products that may interact with this drug include aliskiren, ace inhibitors such as captopril, lisinopril , angiotensin ii receptor blockers such as valsartan, losartan , cidofovir, corticosteroids such as prednisone , cyclosporine, lithium, methotrexate, pemetrexed.

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