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Initial therapy with the combination of januvia and metformin provided significant improvements in a1c, fpg, and 2-hour ppg compared to placebo, to metformin alone, and to januvia alone table 5, figure 1 .

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the us pharma giant filed a lawsuit against glenmark earlier this month after the indian drugmaker started selling copycat versions of januvia sitagliptin and janumet sitagliptin and metformin under the zita and zita met brand names.

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based on the temporal relationship of initiating sitagliptin januvia or sitagliptin metformin janumet and development of acute pancreatitis in reviewed cases, fda believes there may be an association between these events.

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